protocol for studying cough frequency in people with pulmonary tuberculosis - lithium battery pack

Cough is a key symptom of tuberculosis (TB)
And the main reasons for transmission.
However, a recent literature review found that cough frequency (
Cough per hour)
In 1969, only one study was conducted for TB patients.
The main purpose of this study is to describe the pattern of cough frequency before and after the start of TB treatment and to identify baseline factors that affect cough frequency in these patients.
Secondly, we will evaluate the correlation between cough frequency and TB microbial resolution.
Methods this study will select culturally confirmed TB patients from two tertiary hospitals in Lima, Peru.
We estimate that the sample size of 107 patients is sufficient to detect clinically significant changes in cough frequency.
Participants will initially be evaluated by questionnaire, radiology, microscopic observation of drug sensitivity broth TB-
Culture, gold amine smear microscopy and cough records.
This queue will be tracked within the first 60 days
Some microbial samples and 24-hour records will be collected throughout the study.
We will describe the variability of cough onset and determine its association with baseline laboratory parameters for tuberculosis.
In addition, based on potential confounders, we will analyze and predict a decrease in cough frequency when TB is cured.
Ethics and communication ethics approval has been obtained from the ethics committee of each participating hospital in Lima, Peru, the Benfica Association in Lima, Peru, Peruna caritano Heredia University in Lima, Peru and Johns Hopkins University in Baltimore, USA.
Our goal is to publish and disseminate our findings in our peers.
Review journals.
We also want to create and maintain an online repository of cough sounds for TB and the statistical analysis used.
Cough is the main symptom of tuberculosis (TB)
And the main reasons for transmission.
However, a recent literature review found that cough frequency (
Cough per hour)
In 1969, only one study was conducted for TB patients.
The main purpose of this study is to describe the pattern of cough frequency before and after the start of TB treatment and to identify baseline factors that affect cough frequency in these patients.
Secondly, we will evaluate the correlation between cough frequency and TB microbial resolution.
Methods this study will select culturally confirmed TB patients from two tertiary hospitals in Lima, Peru.
We estimate that the sample size of 107 patients is sufficient to detect clinically significant changes in cough frequency.
Participants will initially be evaluated by questionnaire, radiology, microscopic observation of drug sensitivity broth TB-
Culture, gold amine smear microscopy and cough records.
This queue will be tracked within the first 60 days
Some microbial samples and 24-hour records will be collected throughout the study.
We will describe the variability of cough onset and determine its association with baseline laboratory parameters for tuberculosis.
In addition, based on potential confounders, we will analyze and predict a decrease in cough frequency when TB is cured.
Ethics and communication ethics approval has been obtained from the ethics committee of each participating hospital in Lima, Peru, the Benfica Association in Lima, Peru, Peruna caritano Heredia University in Lima, Peru and Johns Hopkins University in Baltimore, USA.
Our goal is to publish and disseminate our findings in our peers.
Review journals.
We also want to create and maintain an online repository of cough sounds for TB and the statistical analysis used.
Tuberculosis (TB)
It is an infectious disease, responsible for 9.
6 million new cases, 1.
5 million people died in 2014.
1 tb spread in air2, 3, cough is the most important cause of transmission.
4 cough in patients with tuberculosis is caused by inflammatory response caused by fungal infection.
The reduction in cough is considered to represent a sufficient response to treatment and lead to a reduction in the risk of transmission of infection.
Although it plays a vital role in TB transmission, a recent literature review reports that cough frequency during TB treatment has not been present since Loudon worked in the 1960 s
Therefore, the frequency of longitudinal cough of TB needs to be studied.
Loudon describes the frequency of cough during the 9-week 8-hour overnight stay.
All sounds whose amplitude and frequency are consistent with possible cough events are recorded and then reviewed manually.
His findings suggest that the average 13 weeks decreased by twice in the first 2 weeks of treatment. 6 to 4. 75 coughs/h.
Colony formation units of 7 tuberculosis branches (CFU)
It was also significantly reduced from 106 at baseline to 103 after two weeks.
This evidence led to drugs.
Patients with TB susceptibility are not enough
In the second week of treatment, they no longer pose a risk to others.
This and other evidence led
The policy of use is that for newly diagnosed patients, 2 weeks is the necessary duration of respiratory isolation and proper treatment begins.
The current evidence and guidelines confirm this position;
However, these 2-14
Policy was criticized this week.
15, 16 our team has proven the drug
Patients with susceptible tuberculosis maintain positive sputum culture for a long time.
17, 18 most importantly, the hypothesis that TB patients no longer cough after 2 weeks has never been confirmed.
2015 chest guidelines recommend acoustic parameters for evaluating cough frequency.
To ensure accurate measurements, it is important to use standardized methods, such as automatic cough counts using validated algorithms.
Although there has been an increasing number of recent literature on this topic, these methods are mainly used for non-
Chronic infectious disease
20-25 while the cough counting algorithm has been validated, 26-30 our study protocol appears to be the first to do so in patients with tuberculosis.
To address this knowledge gap, we developed the Cayetano cough monitor (CayeCoM)
A protocol for studying cough frequency in patients with tuberculosis is described here.
Methods Study purpose the main purpose of this study was to describe the cough frequency pattern of adult tuberculosis patients before and after the start of treatment.
The second objective of this study was to identify baseline features associated with cough frequency, such as patient demographics, radiation findings, multi-drugresistant TB (MDR-TB)and HIV status.
The third objective of this study was to test the association between changes in cough frequency and microbial regression during TB treatment.
This prospective cohort study will be followed up throughout the treatment period for adult tuberculosis patients in Lima, Peru.
Participants diagnosed or suspected of active TB will be referred to our research team.
After obtaining written informed consent, we will record the cough before starting TB treatment.
Participants will provide us with early morning sputum samples to test active tuberculosis disease by using a microscope to observe drug sensitivity test at least one sputum sample (MODS)
Broth culture assay33-35 and gold amine smear microscopy were examined to assess bacterial load.
Patients who have confirmed the diagnosis of tuberculosis with MODS will receive treatment provided by the National TB program in accordance with standard practice.
Figure 1 summarizes the data collected at baseline and within 60 daysup.
Download cayreopen in new tabDownload powerpoint Figure 1 for CayeCoM research.
Monitoring Center for cough in Kayano;
MODS; microscopic observation; drug sensitivity;
Tuberculosis.
Research has shown that Peru is one of the highest rates of tuberculosis in the Americas.
More than one-
The third case of tuberculosis in the Andean region came from Peru.
About the rate of multi-drug resistance
Tuberculosis and a wide range of drugsresistant (XDR)
Tuberculosis in Peru ranks first among all American countries. However, under-
Reports in the region may help Peru's excesses
Representative, such as the latest Pan American Health Organization (PAHO)report.
37 in Peru, Lima and its metropolitan area are the main causes of multi-drug resistance. TB and XDR-TB.
Therefore, we will recruit patients from two hospitals: Mayo National Hospital (HNDM)
The historic center of Lima;
Located in karao, Daniel assides carryon national hospital belongs to the metropolitan area of Lima.
Our main website HNDM is 650-
Bed teaching and public national tertiary referral hospitals managed by the Peruvian Ministry of Health (MINSA).
It serves the poor in the surrounding downtown areas.
HNDM is the only hospital in Peru that provides negative pressure wards for TB patients.
Our second site is another level 3 referral hospital operated by MINSA, the National Hospital of Daniel assides carryon. This 462-
There are bed teaching and health facilities in Callao area.
Infectious diseases and lung doctors will recommend participants to the study group.
The criteria for referral are confirmed cases of active TB suspected of having active TB or not yet under treatment.
Positive TB is defined by positive MODS culture results.
If participants are